New Database Available - Released on 23/03/2024.
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335
Unique InChIKey
42
Unique Sequence
199
EC50 Parameter
21
Unique DOI
BLAST
Gene Name
UniProt ID
% Seq Identity
Species
Mutation
Sequence
Ref. Sequence
OR1A1 Q9TUA7 100 pan troglodytes MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens T99M MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.353 homo sapiens G108A_N109K MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 98.706 homo sapiens G108A_N109K_A154T_N155S MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.353 homo sapiens G108A_G152A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.029 homo sapiens G108A_G152A_I205V MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens G108A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.353 homo sapiens G108A_I205V MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens N109D MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens N109K MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens T110A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.353 homo sapiens D111A_T280A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens D111A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens S112A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens R128H MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens G152A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.353 homo sapiens G152A_I205V MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens V233M MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens S248F MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens Y250F MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens Y251F MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens Y251M MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens V254T MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens Y258F MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens Y258M MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens Y276F MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens Y276L MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens T277M MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens T280A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens T280F MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens T280M MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 100 homo sapiens MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens P285S MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens T277V MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens I205V MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens N155S MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.353 homo sapiens A154T_N155S MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens I114T MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.353 homo sapiens D111S_T280A MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens D111S MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens A106G MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
OR1A1 Q9P1Q5 99.676 homo sapiens A106T MRENNQSSTLEFILL ... MRENNQSSTLEFILL ...
Experiments Pair Aggregation
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UniProt ID
Mutation
Sequence
Molecule Name
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Parameter
Value
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Type
Cell_line
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Gprotein
Co-transfection
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Tag
Reference
DOI
Reference Position
homo sapiens OR1A1 Q9P1Q5 MRENNQSSTLEFILL ... Benzophenone 3102 RWCCWEUUXYIKHB-UHFFFAOYSA-N C1=CC=C(C=C1)C(=O)C2=CC=CC=C2 mono 1 ec50 5.4 uM 3 Luc H3A liquid in vitro olf rpt1s dual-glo luciferase (promega) rho Machine learning assisted appr ... https://doi.org/10.3390/ijms22 ... Table_S2
homo sapiens OR1A1 Q9P1Q5 MRENNQSSTLEFILL ... ethyl 2-(3-bromophenyl)acetate 11470552 CAERSDJFKGMKLY-UHFFFAOYSA-N CCOC(=O)CC1=CC(=CC=C1)Br mono 1 ec50 17.95 uM 3 Luc H3A liquid in vitro olf rpt1s dual-glo luciferase (promega) rho Machine learning assisted appr ... https://doi.org/10.3390/ijms22 ... Table_S2
homo sapiens OR1A1 Q9P1Q5 MRENNQSSTLEFILL ... methyl 2-(2-methylphenyl)acetate 7021479 BLEMRRXGTKTJGT-UHFFFAOYSA-N CC1=CC=CC=C1CC(=O)OC mono 1 ec50 18.6 uM 3 Luc H3A liquid in vitro olf rpt1s dual-glo luciferase (promega) rho Machine learning assisted appr ... https://doi.org/10.3390/ijms22 ... Table_S2
homo sapiens OR1A1 Q9P1Q5 MRENNQSSTLEFILL ... Dipentene 22311 XMGQYMWWDOXHJM-UHFFFAOYSA-N CC1=CCC(CC1)C(=C)C sum of isomers 1 ec50 87.5 uM 3 Luc H3A liquid in vitro olf rpt1s dual-glo luciferase (promega) rho Machine learning assisted appr ... https://doi.org/10.3390/ijms22 ... Table_S2
homo sapiens OR1A1 Q9P1Q5 MRENNQSSTLEFILL ... 1,10-phenanthroline 1318 DGEZNRSVGBDHLK-UHFFFAOYSA-N C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 mono 0 ec50 n.d n.d 300 uM 3 Luc H3A liquid in vitro olf rpt1s dual-glo luciferase (promega) rho Machine learning assisted appr ... https://doi.org/10.3390/ijms22 ... Table_S2
homo sapiens OR1A1 Q9P1Q5 MRENNQSSTLEFILL ... acetophenone 7410 KWOLFJPFCHCOCG-UHFFFAOYSA-N CC(=O)C1=CC=CC=C1 mono 0 raw 30 uM 2 Ca2+ HeLa/Olf liquid in vitro olf gtpγs aciii cnga2 flipr rho Structural determinants of odo ... https://doi.org/10.1016/j.jsb. ... Figure_S2
homo sapiens OR1A1 Q9P1Q5 G108A_N109K_A154T_N155S MRENNQSSTLEFILL ... (S)-(-)-citronellol 7793 QMVPMAAFGQKVCJ-JTQLQIEISA-N C[C@@H](CCC=C(C)C)CCO mono 0 ec50 n.d n.d 300 uM 2 Ca2+ HeLa/Olf liquid in vitro olf gtpγs aciii cnga2 flipr rho Structural determinants of odo ... https://doi.org/10.1016/j.jsb. ... Table_S1
homo sapiens OR1A1 Q9P1Q5 MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 116.69 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 A106G MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 366.69 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 A106T MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 >450 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 G108A MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 196.27 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 N109D MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 0 ec50 n.d n.d 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 N109K MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 0 ec50 n.d n.d 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 D111A MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 389.55 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 D111S MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 246.18 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 S112A MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 0 ec50 n.d n.d 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 G152A MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 141.79 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 N155S MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 >800 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 I205V MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 159.12 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 S248F MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 404.47 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 Y250F MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 345.19 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 Y251F MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 >500 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 Y251M MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 0 ec50 n.d n.d 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 Y258F MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 0 ec50 n.d n.d 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 Y258M MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 0 ec50 n.d n.d 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 Y276F MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 115.43 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 Y276L MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 0 ec50 n.d n.d 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 T277M MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 >400 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 T280A MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 1 ec50 231.82 uM 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
homo sapiens OR1A1 Q9P1Q5 T280F MRENNQSSTLEFILL ... (R)-(-)-Carvone 439570 ULDHMXUKGWMISQ-SECBINFHSA-N CC1=CC[C@H](CC1=O)C(=C)C mono 0 ec50 n.d n.d 2000 uM 3 Luc HEK liquid in vitro olf rtp1s gγ13 glosensor-22f rho C. Geithe, J. Protze, F. Kreuc ... https://doi.org/10.1007/s00018 ... Table_S8
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